NAD+ 100mg
NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme found in every living cell, serving as an essential electron carrier in metabolic redox reactions. It exists in oxidised (NAD+) and reduced (NADH) forms and participates in over 500 enzymatic reactions, making it one of the most important molecules in cellular biology.
Research into NAD+ has intensified dramatically following the discovery of its role as a substrate for sirtuins (SIRT1-7), PARP enzymes (DNA repair), and CD38 (immune signaling). These NAD+-consuming enzymes are central to cellular stress response, genomic stability, and metabolic adaptation. Notably, NAD+ levels decline significantly with age — by approximately 50% between ages 40 and 60 — correlating with many age-related pathologies.
Studies have investigated NAD+ supplementation effects on mitochondrial function, DNA repair capacity, stem cell rejuvenation, circadian rhythm regulation, and neurodegeneration. Research has also explored the interplay between NAD+ synthesis pathways (de novo, Preiss-Handler, salvage) and how their relative contributions change with age and metabolic stress.
| SKU | ONX-NAD-500 |
|---|---|
| Purity | 99%+ |
| Molecular weight | 663.43 Da |
| Molecular formula | C21H27N7O14P2 |
| CAS number | 53-84-9 |
| Appearance | White to off-white lyophilised powder |
| Solubility | Reconstitutes in bacteriostatic water |
| Storage | Store at 2–8 °C, protected from light |
| Shelf life | 36 months at 2–8 °C |
Research relevance
- Studied as a central redox cofactor in cellular energy metabolism
- Investigated for its role as a substrate for sirtuin and PARP enzymes
- Examined in research contexts related to mitochondrial function and DNA repair
- Studied for declining tissue levels in cellular-ageing models
Published references
Related research notes
References are provided for scientific background only. They describe preclinical and laboratory research and do not constitute medical, therapeutic, or efficacy claims. This product is sold strictly for research use.
What is NAD+?
NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme found in every living cell, serving as an essential electron carrier in metabolic redox reactions. It exists in oxidised (NAD+) and reduced (NADH) forms and participates in over 500 enzymatic reactions, making it one of the most important molecules in cellular biology.
Where can a laboratory buy NAD+ in the EU?
Onyx Peptides supplies NAD+ for laboratory research across the European Union. We are operated by Vexio j. s. a. (IČO 54214530) in Slovakia and dispatch from within the EU, so there is no customs entry, no import duty and no border hold. Orders placed before 16:00 CET ship the same day, and shipping is free above €100.
How do I verify the batch of NAD+ I receive?
Each vial carries a batch number. Ask us for the Certificate of Analysis of the batch currently in stock — before you order, not after — and check that the batch number on the certificate matches the one printed on the vial. The analysis is performed by Janoshik Analytical, an independent laboratory in Prague, which will confirm a report it issued if you contact them with its identifier.
How is purity verified?
Every batch is independently tested by Janoshik Analytical using HPLC and Mass Spectrometry. A batch-specific Certificate of Analysis — also covering endotoxins and heavy metals — is available on request.
How fast is delivery?
We dispatch from within the EU, same day on orders placed before 16:00 CET. EU delivery typically takes 1–3 business days.
What payment methods do you accept?
We accept bank transfer (SEPA), including SEPA instant payments which usually arrive within seconds. Your order ships as soon as the transfer clears.
How should this be stored?
Store at 2–8 °C, protected from light. Once reconstituted, keep refrigerated and use within 30 days.
What is the intended use?
All products are supplied strictly for in-vitro laboratory and research use only. They are not for human consumption, veterinary, or clinical use.
