MOTS-c 10mg
MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA type-c) is a mitochondrial-derived peptide (MDP) encoded within the 12S ribosomal RNA gene of mitochondrial DNA. Discovered in 2015 by Dr. Pinchas Cohen laboratory at USC, MOTS-c represents a novel class of signaling peptides that originate from the mitochondrial genome.
MOTS-c research has revealed its role as a key regulator of metabolic homeostasis. Studies have documented its effects on AMPK activation, folate-methionine cycle regulation, and cellular metabolism reprogramming. Remarkably, MOTS-c has been shown to translocate to the cell nucleus in response to metabolic stress, where it directly regulates gene expression — a process termed mitonuclear communication.
Often described in the literature as an exercise mimetic, MOTS-c has been reported in preclinical models to produce effects that parallel those of physical exercise — with changes in insulin sensitivity, fatty acid oxidation, and diet-induced weight gain described in rodent studies. Research has also investigated its decline with age and its potential role in the metabolic changes associated with aging.
| SKU | ONX-MOTS-C-5 |
|---|---|
| Purity | 99%+ |
| Molecular weight | 2174.60 Da |
| Molecular formula | C101H152N28O22S2 |
| CAS number | 1627580-64-6 |
| Amino-acid sequence | MRWQEMGYIFYPRKLR |
| Amino-acid count | 16 |
| Appearance | White to off-white lyophilised powder |
| Solubility | Reconstitutes in bacteriostatic water |
| Storage | Store at 2–8 °C, protected from light |
| Shelf life | 36 months at 2–8 °C |
Research relevance
- Studied as a mitochondrial-derived peptide encoded within the 12S rRNA
- Investigated for AMPK-pathway activation and metabolic homeostasis
- Examined for effects on insulin sensitivity in skeletal-muscle models
- Studied as an exercise-responsive regulator of metabolic stress
Published references
Related research notes
References are provided for scientific background only. They describe preclinical and laboratory research and do not constitute medical, therapeutic, or efficacy claims. This product is sold strictly for research use.
What is MOTS-c?
MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA type-c) is a mitochondrial-derived peptide (MDP) encoded within the 12S ribosomal RNA gene of mitochondrial DNA. Discovered in 2015 by Dr.
Where can a laboratory buy MOTS-c in the EU?
Onyx Peptides supplies MOTS-c for laboratory research across the European Union. We are operated by Vexio j. s. a. (IČO 54214530) in Slovakia and dispatch from within the EU, so there is no customs entry, no import duty and no border hold. Orders placed before 16:00 CET ship the same day, and shipping is free above €100.
How do I verify the batch of MOTS-c I receive?
Each vial carries a batch number. Ask us for the Certificate of Analysis of the batch currently in stock — before you order, not after — and check that the batch number on the certificate matches the one printed on the vial. The analysis is performed by Janoshik Analytical, an independent laboratory in Prague, which will confirm a report it issued if you contact them with its identifier.
How is purity verified?
Every batch is independently tested by Janoshik Analytical using HPLC and Mass Spectrometry. A batch-specific Certificate of Analysis — also covering endotoxins and heavy metals — is available on request.
How fast is delivery?
We dispatch from within the EU, same day on orders placed before 16:00 CET. EU delivery typically takes 1–3 business days.
What payment methods do you accept?
We accept bank transfer (SEPA), including SEPA instant payments which usually arrive within seconds. Your order ships as soon as the transfer clears.
How should this be stored?
Store at 2–8 °C, protected from light. Once reconstituted, keep refrigerated and use within 30 days.
What is the intended use?
All products are supplied strictly for in-vitro laboratory and research use only. They are not for human consumption, veterinary, or clinical use.
