Research Notes
Laboratory reference articles on peptide handling, purity verification, storage and what the published literature reports. Written for researchers, not consumers.
Tirzepatide: How One Peptide Activates Two Receptors
A 39-residue sequence engineered from the GIP backbone to bind two different receptors, with a fatty diacid to survive renal clearance.
Read article → October 1, 2026Semaglutide: The Chemistry of a Long-Acting Peptide
Three modifications turn a peptide with a two-minute half-life into one measured in days. A worked example of half-life engineering.
Read article → September 30, 2026Melanotan II: Structure and Melanocortin Receptor Research
A cyclic alpha-MSH analogue built from four separate stability modifications, and one of the most-studied non-selective melanocortin agonists.
Read article → September 29, 2026Tesamorelin: A GHRH Analogue Explained
One modification — a hexenoyl group on the N-terminus — solves the problem that ends native GHRH's activity in minutes. Everything else follows from it.
Read article → September 28, 2026Ipamorelin: Structure, Selectivity and What the Research Shows
A pentapeptide built almost entirely from stability modifications, and the most selective growth hormone secretagogue described in the literature.
Read article → September 25, 2026pH, Solubility and Peptide Stability
Most solubility failures are a peptide sitting at its isoelectric point. Most stability windows are a compromise between deamidation and hydrolysis.
Read article → September 24, 2026Peptide Light Sensitivity: Which Sequences Actually Need Amber Vials
Photosensitivity lives in three amino acids. Whether your sequence contains them determines how much protection is proportionate.
Read article → September 23, 2026Why Peptide Prices Vary So Much Between Suppliers
Same compound, same stated purity, five times the price. Some of the gap is margin. Most of it is sequence length, purification target and testing.
Read article → September 22, 2026Nine Common Peptide Reconstitution Mistakes
The mistakes that come up repeatedly, each with the mechanism behind it, because knowing why prevents the variation you have not seen yet.
Read article → September 21, 2026What ‘Research Use Only’ Actually Means in the EU
EU regulation classifies by intended purpose, not by molecule. That is why the phrase is a regulatory position rather than a disclaimer.
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