Tirzepatide 5mg
Tirzepatide is a synthetic dual GIP/GLP-1 receptor agonist — the first peptide in its class to simultaneously target both incretin pathways. Its structure incorporates a modified GIP sequence with GLP-1 receptor cross-reactivity, plus a C20 fatty diacid moiety for extended half-life through albumin binding.
The dual agonist mechanism represents a significant advancement in metabolic peptide research. In the published literature, GLP-1 receptor activation is associated with glucose-dependent insulin secretion and reduced appetite signalling, while GIP (glucose-dependent insulinotropic polypeptide) receptor activation has been reported to add complementary effects on lipid metabolism and adipose tissue function. Preclinical work describes the combined activation producing metabolic effects greater than either pathway alone.
Preclinical and clinical research has documented tirzepatide effects on glycaemic control, body weight, hepatic lipid content, and cardiovascular risk factors. Studies have demonstrated superior metabolic outcomes compared to selective GLP-1 agonists, driving intense research interest in the GIP pathway contribution to energy balance.
| SKU | ONX-TIRZ-5 |
|---|---|
| Purity | 99%+ |
| Molecular weight | 4813.45 Da |
| Molecular formula | C225H348N48O68 |
| CAS number | 2023788-19-2 |
| Amino-acid sequence | Y-Aib-EGTFTSDYSI-Aib-LDKIAQKAFVQWLIAGGPSSGAPPPS-NH2 |
| Amino-acid count | 39 |
| Appearance | White to off-white lyophilised powder |
| Solubility | Reconstitutes in bacteriostatic water |
| Storage | Store at 2–8 °C, protected from light |
| Shelf life | 36 months at 2–8 °C |
Research relevance
- Studied as a dual GIP and GLP-1 receptor agonist (twincretin)
- Investigated for glucose-dependent insulinotropic signalling
- Examined in research contexts related to energy balance and weight regulation
Published references
Related research notes
References are provided for scientific background only. They describe preclinical and laboratory research and do not constitute medical, therapeutic, or efficacy claims. This product is sold strictly for research use.
What is Tirzepatide?
Tirzepatide is a synthetic dual GIP/GLP-1 receptor agonist — the first peptide in its class to simultaneously target both incretin pathways. Its structure incorporates a modified GIP sequence with GLP-1 receptor cross-reactivity, plus a C20 fatty diacid moiety for extended half-life through albumin binding.
Where can a laboratory buy Tirzepatide in the EU?
Onyx Peptides supplies Tirzepatide for laboratory research across the European Union. We are operated by Vexio j. s. a. (IČO 54214530) in Slovakia and dispatch from within the EU, so there is no customs entry, no import duty and no border hold. Orders placed before 16:00 CET ship the same day, and shipping is free above €100.
How do I verify the batch of Tirzepatide I receive?
Each vial carries a batch number. Ask us for the Certificate of Analysis of the batch currently in stock — before you order, not after — and check that the batch number on the certificate matches the one printed on the vial. The analysis is performed by Janoshik Analytical, an independent laboratory in Prague, which will confirm a report it issued if you contact them with its identifier.
How is purity verified?
Every batch is independently tested by Janoshik Analytical using HPLC and Mass Spectrometry. A batch-specific Certificate of Analysis — also covering endotoxins and heavy metals — is available on request.
How fast is delivery?
We dispatch from within the EU, same day on orders placed before 16:00 CET. EU delivery typically takes 1–3 business days.
What payment methods do you accept?
We accept bank transfer (SEPA), including SEPA instant payments which usually arrive within seconds. Your order ships as soon as the transfer clears.
How should this be stored?
Store at 2–8 °C, protected from light. Once reconstituted, keep refrigerated and use within 30 days.
What is the intended use?
All products are supplied strictly for in-vitro laboratory and research use only. They are not for human consumption, veterinary, or clinical use.
