Melanotan II 10mg
Melanotan II is a synthetic cyclic lactam analogue of alpha-melanocyte-stimulating hormone (α-MSH) that acts as a non-selective agonist across multiple melanocortin receptors (MC1R through MC5R). Developed at the University of Arizona, it has become one of the most widely studied melanocortin peptides in research.
The peptide primary mechanism involves activation of the MC1R receptor on melanocytes, stimulating eumelanin production through the cAMP signaling cascade. This triggers upregulation of tyrosinase and related melanogenic enzymes, resulting in increased melanin synthesis. Research has documented this process extensively in cell culture and animal models.
Due to its non-selective receptor profile, Melanotan II research extends beyond melanogenesis. Studies have investigated its effects through MC3R (energy homeostasis), MC4R (feeding behaviour, sexual function), and MC5R (exocrine gland secretion). This broad activity profile provides researchers with a tool to study the melanocortin system comprehensively, though it also necessitates careful experimental design.
| SKU | ONX-MT2-10 |
|---|---|
| Purity | 99%+ |
| Molecular weight | 1024.18 Da |
| Molecular formula | C50H69N15O9 |
| CAS number | 121062-08-6 |
| Amino-acid sequence | Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-NH2 |
| Amino-acid count | 7 |
| Appearance | White to off-white lyophilised powder |
| Solubility | Reconstitutes in bacteriostatic water |
| Storage | Store at 2–8 °C, protected from light |
| Shelf life | 36 months at 2–8 °C |
Research relevance
- Studied as a non-selective melanocortin-receptor agonist
- Investigated for melanogenesis via MC1R signalling
- Examined for appetite and energy-balance effects via MC4R pathways
Published references
Related research notes
References are provided for scientific background only. They describe preclinical and laboratory research and do not constitute medical, therapeutic, or efficacy claims. This product is sold strictly for research use.
What is Melanotan II?
Melanotan II is a synthetic cyclic lactam analogue of alpha-melanocyte-stimulating hormone (α-MSH) that acts as a non-selective agonist across multiple melanocortin receptors (MC1R through MC5R). Developed at the University of Arizona, it has become one of the most widely studied melanocortin peptides in research.
Where can a laboratory buy Melanotan II in the EU?
Onyx Peptides supplies Melanotan II for laboratory research across the European Union. We are operated by Vexio j. s. a. (IČO 54214530) in Slovakia and dispatch from within the EU, so there is no customs entry, no import duty and no border hold. Orders placed before 16:00 CET ship the same day, and shipping is free above €100.
How do I verify the batch of Melanotan II I receive?
Each vial carries a batch number. Ask us for the Certificate of Analysis of the batch currently in stock — before you order, not after — and check that the batch number on the certificate matches the one printed on the vial. The analysis is performed by Janoshik Analytical, an independent laboratory in Prague, which will confirm a report it issued if you contact them with its identifier.
How is purity verified?
Every batch is independently tested by Janoshik Analytical using HPLC and Mass Spectrometry. A batch-specific Certificate of Analysis — also covering endotoxins and heavy metals — is available on request.
How fast is delivery?
We dispatch from within the EU, same day on orders placed before 16:00 CET. EU delivery typically takes 1–3 business days.
What payment methods do you accept?
We accept bank transfer (SEPA), including SEPA instant payments which usually arrive within seconds. Your order ships as soon as the transfer clears.
How should this be stored?
Store at 2–8 °C, protected from light. Once reconstituted, keep refrigerated and use within 30 days.
What is the intended use?
All products are supplied strictly for in-vitro laboratory and research use only. They are not for human consumption, veterinary, or clinical use.