SNAP-8 10mg
SNAP-8 (Acetyl Octapeptide-3) is a synthetic octapeptide that mimics the N-terminal end of SNAP-25 (Synaptosomal-Associated Protein of 25 kDa), a key component of the SNARE complex responsible for neurotransmitter vesicle fusion and release at the neuromuscular junction.
Research into SNAP-8 focuses on its mechanism as a competitive inhibitor of the SNARE complex assembly. By binding to the SNARE complex in place of native SNAP-25, SNAP-8 reduces the efficiency of vesicle docking and neurotransmitter release, leading to decreased muscular contraction signaling. This mechanism has been extensively studied in cell culture models of neuromuscular function.
SNAP-8 is primarily researched as a topical compound due to its target at the neuromuscular junction of superficial muscles. Studies have investigated its penetration through skin models, dose-dependent effects on muscle contraction markers, and stability in various formulation matrices. The 500mg format supports research requiring bulk quantities for formulation development and penetration studies.
| SKU | ONX-SNAP8-500 |
|---|---|
| Purity | 99%+ |
| Molecular weight | 1075.24 Da |
| CAS number | 868844-74-0 |
| Amino-acid sequence | EEMQRRAD |
| Amino-acid count | 8 |
| Appearance | White to off-white lyophilised powder |
| Solubility | Reconstitutes in bacteriostatic water |
| Storage | Store at 2–8 °C, protected from light |
| Shelf life | 36 months at 2–8 °C |
Research relevance
- Studied as an acetyl octapeptide modelled on the SNAP-25 protein
- Investigated for modulation of the SNARE complex in neuromuscular research
- Examined in topical expression-line cosmetic models
Published references
Related research notes
References are provided for scientific background only. They describe preclinical and laboratory research and do not constitute medical, therapeutic, or efficacy claims. This product is sold strictly for research use.
What is SNAP-8?
SNAP-8 (Acetyl Octapeptide-3) is a synthetic octapeptide that mimics the N-terminal end of SNAP-25 (Synaptosomal-Associated Protein of 25 kDa), a key component of the SNARE complex responsible for neurotransmitter vesicle fusion and release at the neuromuscular junction.
Research into SNAP-8 focuses on its mechanism as a competitive inhibitor of the SNARE complex assembly.
Where can a laboratory buy SNAP-8 in the EU?
Onyx Peptides supplies SNAP-8 for laboratory research across the European Union. We are operated by Vexio j. s. a. (IČO 54214530) in Slovakia and dispatch from within the EU, so there is no customs entry, no import duty and no border hold. Orders placed before 16:00 CET ship the same day, and shipping is free above €100.
How do I verify the batch of SNAP-8 I receive?
Each vial carries a batch number. Ask us for the Certificate of Analysis of the batch currently in stock — before you order, not after — and check that the batch number on the certificate matches the one printed on the vial. The analysis is performed by Janoshik Analytical, an independent laboratory in Prague, which will confirm a report it issued if you contact them with its identifier.
How is purity verified?
Every batch is independently tested by Janoshik Analytical using HPLC and Mass Spectrometry. A batch-specific Certificate of Analysis — also covering endotoxins and heavy metals — is available on request.
How fast is delivery?
We dispatch from within the EU, same day on orders placed before 16:00 CET. EU delivery typically takes 1–3 business days.
What payment methods do you accept?
We accept bank transfer (SEPA), including SEPA instant payments which usually arrive within seconds. Your order ships as soon as the transfer clears.
How should this be stored?
Store at 2–8 °C, protected from light. Once reconstituted, keep refrigerated and use within 30 days.
What is the intended use?
All products are supplied strictly for in-vitro laboratory and research use only. They are not for human consumption, veterinary, or clinical use.
