Semax 5mg
Semax is a synthetic peptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10), with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. Developed at the Institute of Molecular Genetics in Moscow, Semax has been extensively studied for its neuroprotective and nootropic properties.
Preclinical research has documented Semax involvement in multiple neurological pathways. Studies have investigated its effects on BDNF and NGF expression, dopaminergic and serotonergic system modulation, and cerebral blood flow regulation. The peptide has been studied in models of cognitive impairment, ischaemic injury, and neurodegenerative conditions.
One of Semax most studied properties is its effect on neurotrophin expression — research has shown upregulation of BDNF, NGF, and TrkB receptor activity in brain tissue. This trophic support mechanism is of particular interest in the context of neuroplasticity and neuroprotection research.
| SKU | ONX-SEMAX-30 |
|---|---|
| Purity | 99%+ |
| Molecular weight | 813.91 Da |
| Molecular formula | C37H51N9O10S |
| CAS number | 80714-61-0 |
| Amino-acid sequence | MEHFPGP |
| Amino-acid count | 7 |
| Appearance | White to off-white lyophilised powder |
| Solubility | Reconstitutes in bacteriostatic water |
| Storage | Store at 2–8 °C, protected from light |
| Shelf life | 36 months at 2–8 °C |
Research relevance
- Studied as a synthetic analog of the ACTH(4–10) fragment with neurotropic activity
- Investigated for regulation of BDNF and TrkB expression in the hippocampus
- Examined in preclinical models of cerebral ischaemia and neuroprotection
- Studied for effects on dopaminergic and serotonergic signalling
Published references
Related research notes
References are provided for scientific background only. They describe preclinical and laboratory research and do not constitute medical, therapeutic, or efficacy claims. This product is sold strictly for research use.
What is Semax?
Semax is a synthetic peptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10), with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. Developed at the Institute of Molecular Genetics in Moscow, Semax has been extensively studied for its neuroprotective and nootropic properties.
Where can a laboratory buy Semax in the EU?
Onyx Peptides supplies Semax for laboratory research across the European Union. We are operated by Vexio j. s. a. (IČO 54214530) in Slovakia and dispatch from within the EU, so there is no customs entry, no import duty and no border hold. Orders placed before 16:00 CET ship the same day, and shipping is free above €100.
How do I verify the batch of Semax I receive?
Each vial carries a batch number. Ask us for the Certificate of Analysis of the batch currently in stock — before you order, not after — and check that the batch number on the certificate matches the one printed on the vial. The analysis is performed by Janoshik Analytical, an independent laboratory in Prague, which will confirm a report it issued if you contact them with its identifier.
How is purity verified?
Every batch is independently tested by Janoshik Analytical using HPLC and Mass Spectrometry. A batch-specific Certificate of Analysis — also covering endotoxins and heavy metals — is available on request.
How fast is delivery?
We dispatch from within the EU, same day on orders placed before 16:00 CET. EU delivery typically takes 1–3 business days.
What payment methods do you accept?
We accept SEPA bank transfer (−2 %), cryptocurrency (−5 %), cash on delivery (+€1.50). Bank-transfer orders are dispatched as soon as the payment clears; SEPA instant transfers usually arrive within seconds.
How should this be stored?
Store at 2–8 °C, protected from light. Once reconstituted, keep refrigerated and use within 30 days.
What is the intended use?
All products are supplied strictly for in-vitro laboratory and research use only. They are not for human consumption, veterinary, or clinical use.
